منابع مشابه
Threonine Biosynthesis Pathway Simulation Using IBMDE with Parameter Estimation
When analysing a metabolic pathway through mathematical model, it is important that the significant parameters are being correctly estimated. However, this process often comes across problems such as easily being trapped in local minima, repetitive exposure to worse results during the search process, and occurrence of noisy data. Thus, an improved Bee Memory Differential Evolution algorithm (IB...
متن کاملGlutamic acid inhibition of aspartic acid utilization in threonine biosynthesis.
The observation that Leuconostoc dextranicum 8086 requires either aspartic acid or threonine for growth resulted in studies in which a ri%e’ of aspartic acid in the biosynthesis of threonine was demonstrated in certain lactobacilli (1). In the present investigation, the nature of the requirement for either aspartic acid or threonine for growth of L. dextranicum 8086 has been found to be the res...
متن کاملLysine and threonine biosynthesis in sorghum seeds: characterisation of aspartate kinase and homoserine dehydrogenase isoenzymes
Aspartate kinase (AK, EC 2.7.2.4) and homoserine dehydrogenase (HSDH, EC 1.1.1.3) have been partially purified and characterised from immature sorghum seeds. Two peaks of AK activity were eluted by anion-exchange chromatography [diethylaminoethyl (DEAE)-Sephacel] with 183 and 262 mM KCl, and both activities were inhibited by lysine. Similarly, two peaks of HSDH activity were eluted with 145 and...
متن کاملIntracellular localization of aspartate kinase and the enzymes of threonine and methionine biosynthesis in green leaves.
The intracellular localization of several aspartate pathway enzymes has been studied in pea (Pisum sativum cv Feltham First) and barley (Hordeum vulgare cv Julia) leaves. Protoplast lysates were fractionated by differential or sucrose density gradient centrifugation, in media optimized for each enzyme. The results show that aspartate kinase, homoserine kinase, threonine synthase, and cystathion...
متن کاملThreonine biosynthesis. On the pathway in fungi and bacteria and the mechanism of the isomerization reaction.
The observation that an Escherichia coli mutant requiring exogenous succinate for aerobic growth would alternatively respond to a mixture of four amino acids (1) has now been explained in the case of three of the amino acids. Thus, N-succinyl-n-diaminopimelic acid has been shown to be an intermediate in the bacterial synthesis of lysine and diaminopimelic acid (a), and 0-succinyl-L-homoserine i...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97130-9